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KMID : 1040420220260020086
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Childhood Kidney Diseases
2022 Volume.26 No. 2 p.86 ~ p.90
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Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies
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Lim Ji-Hyeon
Jung Ji-Won
Go Heoun-Jeong
Lee Joo-Hoon
Park Young-Seo
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Abstract
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Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially presenting with hematuria, mild proteinuria, and normal renal function. The first patient with a high myeloperoxidase-ANCA titer (>134 IU/mL) was diagnosed with rapidly progressive glomerulonephritis based on renal biopsy and treated with immunosuppressive therapy after 10 months of follow-up. The second patient with a low myeloperoxidase-ANCA titer (11 IU/mL) maintained normal kidney function without medication. Two cases showed different clinical course according to ANCA titer.
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KEYWORD
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Antineutrophil cytoplasmic antibody, Case reports, Glomerulonephritis, Vasculitis
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